hrp0095p2-46 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Successful treatment with zoledronic acid of a 13-year-old boy with corticosteroid-induced osteoporosis after hematopoietic stem cell transplantation

Athina Vlachopapadopoulou Elpis , Bonataki Myrto , Doulgeraki Artemis , Polyzois Giorgos , Paisiou Anna , Goussetis Eugenios , Peristeri Ioulia , Michalacos Stefanos

Background: Allogeneic hematopoietic stem cell transplantation (HSCT) has emerged as an increasingly successful option to cure a variety of malignant disorders in children. Children benefit from improved survival; however, HSCT is associated with numerous acute and long-term toxicities. Osteoporosis is a well described, late effect of allogeneic HSCT, associated with corticosteroid treatment and patients exposed to cumulative doses >9000 mg/m2 of prednisone...